I'm a 45-year-old, smallish guy. First, the bad news: The first few times I tried to lift the LX200GPS 10-inch scope, the ergonomics did not seem good at all. I was afraid I would dash it on the pavement.
Now, the good news: with practice, I find it easy to mount the scope. I'm no longer afraid of dropping it. I just got used to it, and it isn't a problem. It's easy. But I wouldn't want a bigger scope, because 10 years from now I won't be able to handle anything bigger.
I do the majority of my work with a polar wedge, which eliminates the concern with difficulty in positioning the one central bolt on the bottom. In altazimuth mode, it is the central bolt rather than any question of handles that is the biggest bother, and I think Meade could have done better on the design here. Still, there are fixes for this problem, including inexpensive ones such as "the springy thingy" sold by Scopestuff.com , and more expensive ones such as accessory trays that can be left permanently on your tripod, and which have registration bumpers that make aligning the central bolt easy (see Scopetronix.com ).
I've had the LX200GPS 10-inch for about a year, and I love it. When I use it at home I leave it set up in my garage on a set of Wheely Bars from JMI. It takes 3 minutes to wheel the sucker out. Wheely Bars are a good addition for Celestron, too, I bet.
There is a highly active LX200GPS group in Yahoo! Before you buy, try joining that group and asking questions there.